When it comes to achieving smoother texture, a more even tone or that coveted lit-from-within glow, two in-office treatments consistently rise to the top: Laser Genesis and radio-frequency microneedling (RFMN). While both boost collagen and refine the complexion, the cutting-edge technologies work in fundamentally different ways, and their strengths shine in different scenarios.
We asked dermatologist Dr. Bille Casse to break down exactly when each option makes the most sense.
Laser Genesis: The “Red-Carpet Facial” Glow-Up
If Laser Genesis had a reputation, it would be Hollywood A-list. Known for delivering radiance without downtime, it’s a patient favorite, and Dr. Casse swears by the treatment’s versatility.
“Think of Laser Genesis as gentle laser energy that safely heats the dermis of the skin, thereby creating change such as stimulating collagen,” Dr. Casse explains. “I tell my patients it feels like you are lying at the beach, without a breeze and without any downtime! I call a one-treatment Laser Genesis the Red-Carpet Facial at my office. Your skin looks smooth, bright, and dewy!”
Beyond the immediate glow, results continue to compound. “A series of treatments, your face looks healthy, overall your pigment is more uniform, and there is a decrease in pore size, blemishes, and fine lines!” she adds.
So, who benefits most? Pretty much everyone. “Good news: Laser Genesis is safe for any skin type!” says Dr. Casse, noting its 1064-nm wavelength bypasses epidermal melanin and works safely in the dermis.
Concerns Laser Genesis can treat include everyday dullness, persistent redness, acne, rosacea, scars, and enlarged pores. “Laser Genesis is great for the everyday glow,” she adds. “It can also help treat scars and decrease your pore size.”
Secret by Cutera: Radio-Frequency Microneedling With Laser Options
For deeper collagen remodeling, tightening, and advanced skin revitalization, Dr. Casse turns to her full Secret RFMN portfolio, three devices designed to treat everything from fine lines1 to large pores2.
“Secret RF is a RFMN device that safely creates micro holes with microneedles to trigger your fibroblasts to stimulate collagen*,” explains Dr. Casse. “It is completely customizable, releasing controlled needle depth and uniform radiofrequency energy with minimal downtime†.”
A big plus: Comfort is a priority. Prior to treatment, Dr. Casse applies numbing cream to the treatment area. “The needles are also Teflon-coated so there is no sticking or tearing of the skin, making it more comfortable for my patients,” she adds. And with insulated and non-insulated needle options, she can safely treat darker skin tones. “I have the ultimate control, which makes all the difference.”
Breaking Down the Secret Lineup
“I love the Secret portfolio and have all three devices!” says Dr. Casse.
- Secret RF: “Just what it sounds like, RFMN that is safe and customizable.”
- Secret PRO: Combines fractionated CO₂ with RFMN. The fractionated CO2 component is optimal for skin resurfacing, leaving your skin looking smoother and more even.
- Secret DUO: “Take the RFMN, add a non-ablative 1540 nm wavelength laser, and voila, you have an ideal treatment for all skin types!” The 1540 nm wavelength initiates dermal remodeling without breaking the skin, leading to a faster recovery compared to ablative lasers.
Each device offers “multifunctionality, precision, and results,” says Dr. Casse. “And all three devices can address a wide range of aging concerns from texture3 with Secret RF to pigmentation3,4 with Secret DUO and Secret PRO, improving texture and overall skin quality.”
Why Personalization Matters
Not all RFMN devices are created equal—and Dr. Casse stresses that the Secret platforms stand out for its adaptability. “I can address not only underneath the skin, but also revitalize the surface of the skin,” she says. “I can treat most patients depending on age, skin type, needs, wants, and downtime. I really do feel like I can control the outcome, and that makes me happy.”
Laser Genesis vs. Secret RFMN: Which Should You Choose?
There’s no single answer—and often, Dr. Casse recommends both. It’s important to note that RFMN and Laser Genesis can be performed on different days, but not during the same treatment session.
“Honestly, sometimes I recommend both. I love them both!” she says. For patients over 30 or those showing signs of laxity, she typically leads with Secret RF’s radio-frequency microneedling. Depending on surface concerns and skin type, she may add Secret PRO‘s CO2 ablative laser or Secret DUO’s erbium glass 1540 nm non-ablative laser.
Laser Genesis, on the other hand, shines as a universal glow-getter:
“I often recommend Laser Genesis, especially pre-event. You can get the glow, reduce a breakout, the redness from acne, and it’s amazing for anyone who needs a little pick-me-up!” she says. “Everyone appreciates when their skin looks refined and smooth—there is nothing like that confidence.”
Connect with a trusted provider and find a Secret by Cutera or Laser Genesis provider near you.
*Via electro coagulation and hemostasis. †Downtime may vary.
1 Anwer W, et al. A retrospective study of non-insulated microneedle radiofrequency on wrinkles of facial photoaging subjects. Lasers Med Sci. 2024;39(1):221. Published 2024 Aug 22. doi:10.1007/s10103-024-04048-5 2 Cho SI, et al. Evaluation of the clinical efficacy of fractional radiofrequency microneedle treatment in acne scars and large facial pores. Dermatol Surg. 2012;38(7 Pt 1):1017-1024. doi:10.1111/j.1524-4725.2012.02402.x 3 Naouri M, Mazer JM. Non-insulated microneedle fractional radiofrequency for the treatment of scars and photoaging. J Eur Acad Dermatol Venereol. 2016;30(3):499-502. doi:10.1111/jdv.12890. 4 Tierney EP, Hanke CW. Fractionated carbon dioxide laser treatment of photoaging: prospective study in 45 patients and review of the literature. Dermatol Surg. 2011;37(9):1279-1290. doi:10.1111/j.1524-4725.2011.02082.x
Indications for Use: The xeo+, excel V+ and excel HR (1064 nm Nd:YAG – Laser Genesis Treatment) is indicated for: removal of unwanted hair; stable long-term, or permanent hair reduction through selective targeting of melanin in hair follicles; treatment of pseudofolliculitis barbae (PFB); coagulation and hemostasis of benign vascular lesions such as, but not limited to, hemangiomas, port wine stains, telangiectasias, rosacea, venous lakes, leg veins, spider veins and poikiloderma of Civatte; treatment of wrinkles such as, but not limited to, periocular and perioral wrinkles; reduction of red pigmentation in hypertrophic scars where vascularity is an integral part of the scar; treatment of warts; treatment of mild to moderate inflammatory acne vulgaris. Important Safety Information: The following treatment-related expected transient side effects and possible adverse events may occur during or following treatment with xeo+, excel V+ and excel HR (1064 nm Nd:YAG – Laser Genesis Treatment): Erythema; Edema; Purpura; Hyperpigmentation; Hypopigmentation; Burns; Erosion; Epidermal crusting; Blistering; Scarring; Deep tissue injury; Prolonged wound healing; Temporary or permanent gray hair; Stimulation of terminal hair growth; Undesired hair loss in hair-bearing areas; Red rash/bumps; Hemosiderin staining; Textural changes; Cutaneous indentations; Itching/dry skin; Sun exposure, tanning beds, and artificial tanning mat increase the risk of side effects and adverse events. Some discomfort may be experienced during treatment. Pain may include the feeling of burning, stinging, and radiating pain. Contraindications: Pregnant patients; patients undergoing treatment for skin cancer. In Canada, contraindications also include dysplastic nevi; Accutane if taken in the prior 6 months; photosensitizing drugs (Tetracycline, etc.); bleeding disorders or history of coagulopathies. Warnings: Do not treat over dysplastic nevi or questionable pigmented lesions. Do not treat over open wounds. Do not treat over or close to tattoos or permanent make-up. Do not treat over or close to metal or electronic implants. Do not treat over tanned skin. Treatment of tanned skin should be delayed to avoid complications.
Indications for Use: Secret RF radiofrequency microneedling (RFMN) is indicated for use in dermatologic and general surgical procedures for electro-coagulation and hemostasis. Additional Laser Treatment Indications: Secret DUO (i) — The 1540 nm wavelength is indicated for dermatologic procedures requiring the coagulation of soft tissue, as well as for skin resurfacing procedures. Secret PRO (ii) — The CO2 Laser is indicated for Fractional Mode: ablative skin resurfacing and for Surgical Mode: incision, excision, ablation, vaporization and coagulation of soft body tissue, including intraoral tissue, in fields including aesthetics (dermatology and plastic surgery), otorhinolaryngology (ENT), gynecology, neurosurgery, dental and oral surgery and genitourinary surgery. Contraindications: Patients using a pacemaker or another implantable metal medical device, Patients with an unknown skin disease, Pregnant women, Patients who have a piercing on the treatment area, Patients with a hemostatic disorder, Patients who are receiving treatment for skin cancer or have a history of cancer, Patients who have symptoms such as sores, psoriasis, eczema, or a rash on the treatment area, Patients who are sensitive to hot sensation or who have any type of suspected lesions on the treatment area, Patients who have any immunosuppressive disease such as AIDS and HIV or any immune system disorder due to the use of immunosuppressants. Additional warnings and precautions can be discussed during a treatment consultation. Important Safety Information and Warnings: The following adverse effects can also occur when treating with the Secret RF, DUO, and PRO System for all indications: discomfort/pain, swelling, redness, skin color changes, milia/acne, wounds, contact/allergic dermatitis or skin sensitivity, infection, scarring, treatment pattern, petechiae, dilated pores, sun exposure/tanning beds/artificial tanning, allergy. Additional Laser Treatment Important Safety Information and Warnings: The following adverse effects can occur when treating with the 1540 nm and CO2 Laser systems for all indications: (i) Secret DUO 1540 nm Laser Treatment — Pigmentation change; Temporary pain; Erythema; Edema. (ii) Secret PRO CO2 — Ectropion may occur very rarely in patients receiving treatment around the eyelids.